Zenuo Biotech 
**Metandienone (Dianabol)** is an anabolic steroid with the scientific name methylandrostenone. It was first developed by Ciba Pharmaceuticals in
the 1950s to promote muscle growth and strength. Although it was originally used in the medical field, it has gained widespread attention in the
bodybuilding and sports fields for its powerful muscle-building effects. Due to its side effects and risk of abuse, it is currently banned or strictly controlled in many countries.
### **Main applications**
#### **1. Medical uses (historically legal uses)**
Among legal medical applications, Metandienone is mainly used to treat the following diseases, but it has been gradually replaced by safer drugs:
- **Muscular dystrophy:**
Used to improve muscle loss caused by chronic diseases (such as cancer or AIDS), increase weight and strength.
- **Stunned growth or developmental delay:**
In some cases, it is used to treat developmental disorders in children and promote bone and muscle growth.
- **Specific types of anemia:**
Improve anemia symptoms by stimulating red blood cell production.
#### **2. Bodybuilding and Sports (Illegal or Abuse)**
Metandienone is best known for its non-medical use in bodybuilding and strength training, although such use is generally illegal.
- **Promoting Muscle Growth:**
- Dianabol significantly increases muscle mass and strength by increasing protein synthesis and nitrogen balance.
- It has a rapid onset of action compared to other steroids, and significant muscle gains are usually seen within a few weeks.
- **Enhancing Strength and Endurance:**
Many bodybuilders and athletes use it to enhance athletic performance, especially in strength-based sports such as weightlifting.
- **Stacking Use:**
Often used with other steroids such as testosterone or Deca-Durabolin to form a "stack" to maximize the effect.
### **Pharmacological Mechanism of Action**
Metandienone works by mimicking the effects of testosterone:
1. Enhances protein synthesis in muscle cells.
2. Improves muscle's ability to retain nitrogen and improves metabolic efficiency.
3. Increase red blood cell production, improve oxygen transport capacity, and improve endurance.
### **Side effects and risks**
Due to abuse and improper use, Metandienone is often accompanied by serious side effects:
- **Hepatotoxicity:**
Dianabol is a 17α-alkylated steroid that can be metabolized by the liver but has a high burden on the liver. Long-term use may cause liver damage or liver cancer.
- **Cardiovascular problems:**
Causes increased low-density lipoprotein (LDL) and decreased high-density lipoprotein (HDL), increasing the risk of heart disease.
- **Androgenic effects:**
Such as acne, hair loss, increased sebum secretion and other problems, especially in men.
- **Endocrine suppression:**
Inhibits natural testosterone secretion. Long-term use may cause testicular atrophy and hormone imbalance.
- **Female masculinization:**
In women, it may cause masculine characteristics such as deep voice, body hair growth, and menstrual disorders.
### **Regulations and restrictions**
- In many countries (including the United States, the United Kingdom, China, etc.), Metandienone is classified as a controlled drug, and non-medical use
and unauthorized sales are illegal.
- The World Anti-Doping Agency (WADA) explicitly prohibits its use in all sports.
### **Legal research and development direction**
Although the direct application of Metandienone is restricted, its pharmacological properties provide a basis for the development of other new drugs.
Research can be carried out in the following directions:
1. **Structural optimization:**
Develop derivatives with lower toxicity but still strong anabolic activity.
2. **Topical application:**
Explore local medications (such as ointments or patches) to reduce systemic side effects.
3. **Treatment of specific populations:**
Small doses and short-term applications for myasthenia gravis, severe trauma or rehabilitation populations.
### **Conclusion**
Metandienone was mainly used for muscle enhancement and strength improvement in medical history, but it is no longer recommended for human
treatment due to its side effects and risk of abuse. Its modern use is concentrated in the fields of basic research and new drug development, while its
use in bodybuilding and sports falls into the category of illegal abuse.